Breast carcinoma (BC) is one of the leading causes of female mortality worldwide. Triple-negative breast carcinoma (TNBC) is a subgroup and represents one of the most aggressive and difficult-to- treat forms of breast cancer characterized by a high adaptive capacity of tumor cells to the surrounding mechanical environment. The translation of microenvironmental stimuli into changes in cellular function is dependent on the presence of a molecular machinery capable of sensing and responding to these forces. Once received, the signal is amplified and propagated through several intracellular mediators. Among these, NDRG1 represents a signal node from many membrane receptors1. Through a multidisciplinary approach that combines the development of biomaterials, cellular biology, and correlative microscopy, this project aims to study the molecular mechanisms regulating BC/TNBC cell progression in response to changes in extracellular mechanical forces, focusing on the role of the NDRG-1 factor in the mechanisms that regulate the migration and invasiveness.]