Upon FDA approval of gadolinium-based contrast agents for MRI, Gd-chelates have been widely utilized to enhance imaging quality, especially in the brain. Thanks to its large absorption coefficient Gd is also suitable for Computed Tomography, but recently severe concerns about stability and safety upon injection have been raised. Nevertheless, in the last years inorganic nanomaterials have gained prominence in medical imaging due to their customizable compositional and physicochemical properties, enabling detailed visualization of structures and processes at multiple levels. Gd-doped nanoparticles may serve as powerful tools for trimodal imaging by both CT, MRI and fluorescence imaging. The proposal aims to develop Gd-doped ZnO nanoparticles for diagnosing brain cancer through trimodal imaging and is intended as a multidisciplinary platform that includes complementary competences and combines multiple microscopy techniques. The project outline is organized in 3 Work Packages, 5 main Objectives, 7 Deliverables and 5 Milestones in a time frame of 24 months.