Conventional amputation prostheses rely on a socket attached to the stump, which can lead to soft tissue complications. Intraosseous Transcutaneous Amputation Prostheses (ITAP) offer a more stable solution by directly loading the skeleton, but infections at the abutment-skin interface remain a major challenge. This interface, where the implant penetrates the skin, is vulnerable to microbial invasion, leading to issues like epithelial downgrowth and marsupialization. BIOFIT-PRO project aims to address these challenges by developing a novel bilayer scaffold designed to enhance ITAP integration and prevent infection. The scaffold consists of a sealing layer made from polyvinyl alcohol (PVA), which acts as a barrier to microbial penetration, and a bioactive layer made from porous cryogels (GelMA and PEGDA) that promotes tissue ingrowth. The project focuses on the design, fabrication, and characterization of these hydrogels using 3D bioprinting and other advanced techniques. In vitro testing will evaluate the mechanical, biological, and infection resistance properties of the scaffold. The goal is to create a biocompatible, mechanically stable scaffold that improves ITAP implant integration, reduces infection risks, and addresses long- standing issues at the abutment-skin interface.